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Skin infection generates non-migratory memory CD8+ T cells providing global skin immunity.
Jiang X, Clark RA, Liu L, Wagers A, Fuhlbrigge RC, Kupper TS
Nature. 2012 Published online Feb 29; (doi: 10.1038/nature10851)

Old and new: recent innovations in vaccine biology and skin T cells.
Kupper TS
J Invest Dermatol. 2012 Mar; 132(3 Pt 2): 829-34
PMID: 22237702

Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients.
Clark RA, Watanabe R, Teague JE, Schlapbach C, Tawa MC, Adams N, Dorosario AA, Chaney KS, Cutler CS,
Leboeuf NR, Carter JB, Fisher DC, Kupper TS
Sci Transl Med. 2012 Jan 18; 4(117): 117ra7
PMID: 22261031

Resident memory T cells (T(RM)) are abundant in human lung: diversity, function and antigen specificity.
Purwar R, Campbell J, Murphy G, Richards WG, Clark RA, Kupper TS
PLoS One. 2011 Jan 26; 6(1): e16245
PMID: 21298112

Skin-resident T cells: the ups and downs of on site immunity.
Clark RA
J Invest Dermatol. 2010 Feb; 130(2): 362-70
PMID: 19675575

Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity.
Liu L, Zhong Q, Tian T, Dubin K, Athale SK, Kupper TS
Nat Med. 2010 Feb; 16(2): 224-7
PMID: 20081864

Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells.
Clark RA, Huang SJ, Murphy GF, Mollet IG, Hijnen D, Muthukuru M, Schanbacher CF, Edwards V, Miller DM, Kim JE, Lambert J, Kupper TS
J Exp Med. 2008 Sep 29; 205(10): 2221-34
PMID: 18794336

IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin.
Clark RA, Kupper TS
Blood. 2007 Jan 1; 109(1): 194-202
PMID: 16968902

The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors.
Hirahara K, Liu L, Clark RA, Yamanaka K, Fuhlbrigge RC, Kupper TS
J Immunol. 2006 Oct 1; 177(7): 4488-94
PMID: 16982885

Dynamic programming of CD8+ T cell trafficking after live viral immunization.
Liu L, Fuhlbrigge RC Karibian K, Tian T, Kupper TS
Immunity. 2006 Sep; 25(3): 511-20
PMID: 16973385

A novel method for the isolation of skin resident T cells from normal and diseased human skin.
Clark RA, Chong BF, Mirchandani N, Yamanaka K, Murphy GF, Dowgiert RK, Kupper TS
J Invest Dermatol. 2006 May; 126(5): 1059-70
PMID: 16484986

The vast majority of CLA+ T cells are resident in normal skin.
Clark RA, Chong B, Mirchandani N, Brinster NK, Yamanaka K, Dowgiert RK, Kupper TS
J Immunol. 2006 April 1: 176)7): 4431-9
PMID: 16547281